Partners in Cancer Research
The NSABP Foundation, Inc. has designed and conducted clinical trials for over 50
years that have changed the standard of treatment in breast and colorectal cancer.
The NSABP is a not-for-profit clinical trials cooperative group supported primarily
through grants from the National Cancer Institute and in part from the Tobacco Settlement
Act and other sources.
The NSABP pioneered breast cancer studies that led to the establishment of lumpectomy
plus radiation over mastectomy as the standard surgical treatment for breast cancer.
We were also the first to demonstrate that adjuvant therapy (treatment in addition
to surgery) could alter the natural history of breast cancer, increasing survival
rates, and demonstrating on a large scale the preventive effects of the drugs tamoxifen
and raloxifene in reducing rates of invasive breast cancer.
The NSABP began research in colorectal cancer in 1977 and since then has randomized
nearly 15,000 patients into large Phase III colorectal studies. The data from these
trials have significantly influenced the treatment of colorectal cancer. A trial
that finished in 1990 ultimately established the standard of care for chemotherapy
following removal of the primary tumor in colon cancer patients.
The NSABP Foundation, Inc., headquartered in Pittsburgh, PA, has more than 700 research
sites in North America and an international network of oncology and research professionals.